Disease

Chronic myeloid Leukemia Leukemia is a type of cancer that affects the broth and fig up means. Chronic myeloid leukemia (CML) is a myeloproliferative dis define characterized hematologically by marked leukocytosis, basophilia, and eosinophilia, the leukocytosis is due primarily to an increase in grow and immature neutrophils. CML is a clonal disorder associated in virtually all cases with a t(9;22)chromosome usually manifest as the Philadelphia (Ph) chromosome, molecular(a) evidence of the translocation of the abl oncogene from chromosome 9 to the breakpoint cluster region (bcr) of chromosome 22. (Rajendra Persad 2001) theory study of CML/ Patient history: The patient is a 58 year old white female who was diagnosed with Chronic myeloid Leukemia (CML) positive for the Philadelphia chromosome by classical cytogenetics, seven months previously. A bring forward b peer slight marrow performed five months after diagnosis, to bank bill resolution to interferon and hydrox yurea treatment findings consistent with CML, with persistence of the Ph chromosome and less than 1% blasts. She is now being evaluated prior to bone marrow transplant. (Rajendra Persad 2001) PB Count: Hb11.1 g/dl(normal 11.7 -15.7) Plt246 x10E+9/L(normal 150 -450) WBC84.2 x10E+9/L(normal 4.5 -11.0) Blasts(1%) 0.84(normal < 0.02) Promyelocyte (1%) 0.84 Promyelocyte(1%) 0.

84 Myelocytes(5%) 4.21 Metamyelocytes(9%) 7.58 Bands(23%) 19.37(normal 0.1 -0.8) Polys(43%) 36.22(normal 2.0 - 6.8) Basophils (2%) 1.68 (normal < 0.2) A bone marrow aspirate, with the following derivative instrument: Blasts19% (normal 0.0 -2.0) Basophils5.3% (normal 0.0 - 0.2) ! M:E ratio 6.1% (normal 1.5 - 3.3) Ph chromosome positive The incidence of CML is 1-1.5/ 100 000 population, constituting 15-20 % of all leukemias, do it the commonest of the chronic myeloproliferative disorders. With a average age of 53years, about one third of patients are previous(a) than 60 years. CML is uncommon in childhood, accounting for...If you want to constrict a full essay, order it on our website: OrderCustomPaper.com

If you want to get a full essay, visit our page: write my paper