Stages of Alzheimers Utilizing Machine Learning Techniques

Stages of Alzheimers Utilizing Machine culture TechniquesAbstractAlzheimers indisposition (AD) is the general type of dementia that affects the elderly population world-widely. An accurate and primaevalish diagnosis of Alzheimer is crucial for the treatment of patients suffering from AD. In this paper, two different classifiers, SVM (Support Vector Machine) and an ANFIS (Adaptive Neuro Fuzzy proof System) have been utilise to split patients between AD supremacy, mild control and normal control. The system employed magnetic resonance imaging (Magnetic Resonance Imaging) entropy obtained from the ADNI data trammel of 150 subjects consisting of 75 normal controls, 50 mild controls and 25 AD controls. Initially, image processing techniques like segmentation and feature extraction argon applied on these magnetic resonance imaging images to enhance the classification verity. The segmentation is performed using k-means clustering and a GLCM (Gray Level Co-Occurrence Matrix) ar apply to extract the 2D features of the left ventricle of the wittiness. The extracted features be then utilize to train the classifiers and the results obtained from both classifiers are then compared. It is shown that the classification accuracy of ANFIS is more when compared to that of SVM classifier.Keywords Alzheimer, MRI (Magnetic Resonance Imaging), ANFIS (Adaptive Neuro Fuzzy Inference System), SVM (Support Vector Machine).1. entrancewayAlzheimers ailment is a neurodegenerative syndrome 1 of the brain tissues that results in progressive and permanent loss of mental function. The disease generally starts with mild indications and ends with severe damage in brain. The pathophysiology of the disease is associated with the damage and death of the neurons, originating in the genus Hippocampus component part of the brain that is involved with learning and memory, then atrophy impacts the whole brain. According to epidemiological development Alzheimer affects approximately 2 6 million people all over the world. In recount to give prim care to AD patients, it is vital to measure the amount of atrophy present in the cerebral mantle during the initial stages of AD.The early detection of these diseases can greatly enhance diagnosis. But, diagnosis of this disease depends on the history, neuropsychological tests and clinical assessment. However, the clinical assessment is biased and the neuropsychological test does not provide high accuracy for early stage detection of the disease. In addition to neuropsychological summary, structural imaging is greatly utilized in fellowship to provide suffer to AD diagnosis. The whole brain approach utilized for describing the brain atrophy might be capable of differentiating between AD and MCI (mild cognitive impairment) patients.Recent researches 1, 2 show that the analysis of brain scan images is more consistent and subtle in identifying the presence of Alzheimers disease than the conventional cognitive assessme nt. In this circumstance, some(prenominal) machine learning approaches have been presented in ordering to perform neuroimaging analysis for classification of AD. In addition, all these approaches require training sets that is well categorized anatomical structure in order to associate each new subject that belongs to the test set. Recently MRI data have die center of several machine learning techniques for clearing subjects as CN vs. AD or CN vs. MCI.The focus of this paper is to classify between the different stages of AD utilizing machine learning techniques. Here, all the MRI brain scan images are segmented using k means clustering and the 2D shape features of the ventricles are obtained using GLCM base feature extraction. Then the extracted features are utilized for classification. First, an SVM found classifier is employed to classify the test data into tether categories normal, mild and AD. Second, an ANFIS based classifier is utilized for classification. Finally, the results of the two classifiers are compared and have been shown that ANFIS classifier outperforms SVM classifier.2. Related WorksAlzheimers disease (AD) classification is vital for early detection and diagnosis of the disease. Several studies explored machine learning techniques and artificial countersign for detecting the cerebral changes and differentiate between normal aging and AD patients 1-3. In 4 a support vector machine (SVM) based machine learning approach has been utilized for automatic classification spotless brain anatomical MRI data to differentiate between elderly control and AD control patients. In this study, 16 patients with AD control and 22 patients with elderly control were used. Depending upon the gray matter characteristics extracted from region of interest (ROI), the SVM algorithm is used for classifying the subjects and the arithmetic procedures are based on bootstrap resampling in order to ensure the strength of the results.In 5 a local patch based subspa ce ensemble approach has been proposed that constructs several different classifiers depending on the various subsets of local patches and they are combined for robust and more accurate classification. Here, all(prenominal) brain image is segmented into number of local patches and the subset of patches is selected from the patch pool and a sparse agency based classifier technique has been used in order to construct a low-cal classifier. The multiple weak classifiers are then combined for making final decision. 6 A theoretical account for classifying Alzheimers disease utilizing ADNI dataset is presented. The framework fuses overlap based and registration based similarity measures that are enhanced employing a self-smoothing operator. These enhanced prosody are then employed for the classification of Alzheimer disease.In 7 an automatic classification system for recognizing AD in MRI (structural Magnetic Resonance Imaging) has been developed. The system utilizes visual content des cription of anatomical brain structure (hippocampal region) and fuses two biomarkers CSF and hippocampus in order to enhance the classification accuracy. It is shown that the classification accuracy is more in case of fusion than when utilizing CSF volume or visual features separately. In 8 support vector machines (SVM) were assessed to determine whether data combined from various scanners would provide effective classification. Here, a linear SVM has been employed to classify GM (grey matter) component of T1 weighted MR image. The results show that about 96% of clinically verified AD patients were accurately classified exploiting the integral brain image. 9 Classified between healthy, MCI and AD patients with the help of support vector machine (SVM). The author as well analyzed the accuracy of classification when several anatomical brain regions and various image modalities are combined. Therefore, global and regional grey matter, regional asymmetry coefficients, Ti- quantitativ e MRI data and regional with matter volumes are combined. It shows that an accuracy of 88.3% in case of CTL vs. AD and 81.8 % in case of CTL vs. MCI was attained. In 10 a binary SVM has been proposed to classify patients between mild cognitive impairment and elderly control subjects from MRI images. This approach utilized a Java Agent DEvelopement Framework (JADE) in order to reduce the computation time.3. Materials and MethodsIn this section, the data set and methods utilized in this study as well as the description of the proposed framework depicted in fig 1 are presented.3.1 SubjectsThe data employed in this study were obtained from ADNI (Alzheimers disease Neuroimaging Initiative) database 11. ADNI utilizes biomarker measures and neuroimaging in order to track the changes taking throw ins in the brain of the subjects under study for diagnosing AD at an early stage.Fig 1 Block Diagram of the step involved in the classification of stages of AD3.2 go steady PreprocessingThe colle cted T1 weighted MRI images were free from noise, missing data and outliers. In preprocessing step all the MRI brain images are segmented into VM, GM, CSF and Ventricle tissues that represent vital information about brain retroversion disease. A clustering based segmentation approach has been employed for this purpose. The k means clustering is exploited in order to extract the VM, GM and CSF features the entire MRI brain image. It partitions the data points into k clusters 12 based on the inherent quad between the data points. The intent is to minimize inter cluster variance. For a healthy MRI brain image, k is usually three (corresponding to grey matter, white matter and CSF). afterwards segmenting the MRI brain images into GM, WM and CSF, morphological operations are applied to obtain the binary ventricle tissue. Here, morphological operators such as erosion and dilution are applied.3.3 Feature ExtractionIn order to accurately classify AD patients ventricle shape features are extracted. In this work, the 2D shape features are extracted from the ventricles based on Gray-Level Co-occurrence Matrix (GLCM) feature extraction. This method computes the co-occurrence matrix of each image present in the database by calculating how frequently pixel x with certain intensity value take place in relation with other pixel y at a specific orientation and distance d.The eleven features calculated from every co-occurrence matrix, generates set of feature vectors. These feature vectors include contrast, homogeneity, energy, correlation, mean, variance, rectangularity, elongation, circularity, area and circumference and listed in table 1.Table 1 Extracted Features